| abstract |
The present invention is not only for the treatment of irritable bowel symptoms (IBS), but also for the treatment of chronic pain disorders, or for hypersensitivity to pain signals, hyperalgesia, pain, enhanced perception of pain, and other memories with enhanced memory for pain. Compounds combining selective serotonin (5-HT) reuptake inhibitors (SSRIs) and 5-HT 1A receptor agonists for the preparation of medicaments in the treatment of conditions, in particular 1- [4- (5-cyanoindole- 3-yl) butyl] -4- (2-carbamoyl-benzofuran-5-yl) -piperazine or a physiologically acceptable salt thereof or 3- {4- [4- (4-cyanophenyl) -Piperazin-1-yl] -butyl} -1H-indole-5-carbonitrile or a physiologically acceptable salt thereof. |