http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20030046777-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5b9f9cd8f41ddd9b8e5bc26a4d68518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_694f81756e92c09f407b691917f41467 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate | 2001-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1458c00b9e35b782e4a32a821d119c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8194dabe37b5acab21a3355e43e362e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f8dbabf024c12654519e37160fb86ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07753ec1deecc2790025225e0344fedc |
| publicationDate | 2003-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20030046777-A |
| titleOfInvention | Method for preparing chiral amines |
| abstract | The present invention relates to a method for preparing a chiral amine, which method is prepared by reacting a ketoxime, palladium, lipase, acyl group donor compound and tertiary amine represented by the following formula (I) to prepare an amide of the formula (IV) Hydrolysis of the amide.n n n [Formula I]n n n n n n n n [Formula IV]n n n n n n n n (In the above formulas I and IV,n n n R 1 is hydrogen, an alkyl group, an alkoxy group, a phenyl group, a phenyl group substituted with an alkyl group,n n n R 2 and R 3 are hydrogen or an alkyl group, or R 2 and R 3 is a ring to which the alkyl group is a C 1 to C 3 alkyl group substituted with hydrogen, oxygen, nitrogen, sulfur or halogen, wherein R The linking ring of 2 -R 3 is represented by-(CH 2 ) n -X-, n is a natural number of 1 to 3, X is a methylene group, oxygen, sulfur or nitrogen atom,n n n Y is -CH = CH-, -CH = N-, sulfur or oxygen,n n n R 4 is an alkyl group of C 1 to C 5 substituted with oxygen or halogen.)n n n In the preparation method of the present invention, the chiral amine can be stereoselectively formed in the amide form from the achiral matrix ketoxime by mixing a metal catalyst palladium and a biocatalyst lipase, and the synthesis method of the chiral amine according to the present invention is known in the art. On the contrary, it is a new technology that uses a metal catalyst and a biocatalyst, and has the advantage of using ketoxime, which is relatively easy to manufacture, as a substrate, and providing a high yield of chiral amine with high optical purity.n n n Synthesis method of the present invention is a synthetic method with a large versatility applicable to the synthesis of secondary amines of various structures, it can replace the conventional pure chemical synthesis method or biochemical synthesis method. Chiral amines that can be prepared through the present invention can be usefully used as intermediate raw materials for various chiral pharmaceuticals and fine chemicals. |
| priorityDate | 2001-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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