| abstract |
General formula (1)n n n n n n n n [Wherein A represents a group-(CH 2 ) n- (n represents 1 or 2) or a methine (CH) group, when A is -CH 2- , B represents a methine group or a nitrogen atom, and AB Is a single bond, when A is-(CH 2 ) 2- , B represents a nitrogen atom, AB is a single bond, when A is a methine group, B is a quaternary carbon and AB is a double bond. R 1 and R 2 are the same or different and may represent a hydrogen atom, a lower alkyl group or a cycloalkyl group, or R 1 and R 2 may be combined with adjacent nitrogen atoms to form a heterocycle. Ar represents a phenyl group, a bicyclic aromatic ring, a monocyclic heterocycle, a bicyclic heterocycle or a fluorene group which may have a substituent.] 2,2-diphenylbutanamide derivative or salt thereof.n n n It exhibits excellent μ-opioid agonist action and analgesic action against neuropathic pain and is useful as a drug for peripheral analgesics and neuropathic pain inhibitors. |