abstract |
The present invention relates to polymer-modified bioactive synthetic chemokines and methods of making and using them. Bioactive synthetic chemokines of the present invention include a polymer modified polypeptide chemokine backbone. The compounds and methods of the present invention are directed to abnormalities associated with naturally occurring chemokines, such as the treatment of HIV and AIDS-related abnormalities and the treatment of asthma, allergic rhinitis, atopic dermatitis, atherosclerosis, atherosclerosis, organ transplant rejection and rheumatoid arthritis. It is useful for treatment. |