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filingDate 2001-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c061b63e47998c1fe2c38d63660db4bd
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publicationDate 2003-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20030033486-A
titleOfInvention Methods for detecting binding of biomolecules using shear stress measurements
abstract The present invention measures binding of a probe and a target molecule by measuring a difference in shear stress before and after one surface of a sensor on which a probe such as a nucleic acid or a protein is fixed reacts with the target molecule. It relates to a method of detecting whether or not.n n n According to the detection method of the present invention, unlike the conventional detection method using a fluorescent material by measuring the shear stress (shear stress) of the sensor surface before and after the reaction between the probe and the target molecule, no separate labeling is required, the detection result is an electrical signal There is an advantage that can be obtained. In addition, compared to the conventional method of measuring the degree of deflection of the cantilever (Cantilever) has the advantage that it is more sensitive (sensitive) and does not require a separate expensive equipment such as a laser (Laser).
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