| abstract |
The present invention relates to novel pyrazole compounds of formula III wherein ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic selected from aryl, heteroaryl, heterocyclyl and carbocyclyl Is a click ring, and R x and R y together with the atoms inserted therebetween form a fused unsaturated or partially unsaturated 5-8 membered carbocyclo ring, wherein R 2 and R 2 ′ are as described herein . The compounds are useful as protein kinase inhibitors, especially inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease. |