| abstract |
The present invention provides hemostatic, bioadhesive, prepared from intermolecular large complexes of carboxyl group-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, and optionally comprising polyvalent cations and / or poly cations and / or hemostatic agents. , Bioresorbable, anti-adhesion compositions, and improved methods of making and using the same. The polymers are bonded to each other and dried in the form of a membrane or sponge, or used as a fluid, gel or foam. Hemostasis, bioresorption, bioadhesion, antiadhesion compositions are useful in surgery by inhibiting postoperative bleeding and formation and remodeling of adhesions. The composition is designed to be degraded and removed in vivo. Hemostasis, anti-adhesion, bioadhesion, bioresorption, anti-thrombogen and / or physical properties of the composition may be determined by careful control of pH, solid content in the polymer casting solution, cation content, polyacid composition, polyalkylene oxide composition, Or it can change as needed by adding a hemostatic agent. Hemostatic membranes, gels and / or foams may be used together. Hemostatic, anti-adhesion compositions can also be used to smooth tissues and / or medical instruments, and / or deliver drugs to the surgical site to release them locally. |