abstract |
In the present invention, ring D is a 5 to 7 membered monocyclic ring or an 8 to 10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl, and R x and R y are selected from TR 3 Form independently or together with their intervening atoms, a fused unsaturated or partially unsaturated 5 to 8 membered ring having 1 to 3 ring heteroatoms selected from oxygen, sulfur or nitrogen, and R 2 , R 2 ′ , and T and R 3 describe novel pyrazole compounds of formula VI as described herein. The compounds are useful as protein kinase inhibitors, especially inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease. |