http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20030029812-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5025 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 |
| filingDate | 2001-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20030029812-A |
| titleOfInvention | Chemical compounds |
| abstract | The present invention provides compounds of formula (I) and salts thereof, methods for preparing such compounds, pharmaceutical compositions comprising compounds of formula (I) or pharmaceutically acceptable salts thereof as active ingredients, produce antiangiogenic and vascular permeability reducing effects in warm blooded animals It relates to the use of a compound of formula (I) in the manufacture of a medicament for use. Compounds of formula (I) and their pharmaceutically acceptable salts inhibit the effects of VEGF, a valuable property in the treatment of various diseases including cancer and rheumatoid arthritis. In compounds of formula (I), ring C is a 9 or 10-membered bicyclic heteroaromatic group which may contain one or more nitrogen atoms in the ring attached to Z and may further comprise 1-3 heteroatoms, wherein the heteroatoms are independently O, S and N, provided that ring C is not a quinazoline, quinoline or cynoline group; Any one of G 1 , G 2 , G 3 , G 4 and G 5 is nitrogen and the other 4 is -CH-, or G 1 , G 2 , G 3 , G 4 and G 5 are all -CH- ego; Z is -O-, -NH-, -S-, -CH 2 -or a direct bond; Z is bonded to any one of the free carbon atoms G 1 , G 2 , G 3 and G 4 ; n is an integer of 0-5; Any substituent R 1 may be attached to any free carbon atom of an indole, azaindole or indazole group; m is an integer between 0 and 2; R b represents hydrogen or another example as defined herein; R 1 represents hydrogen, hydroxy, halogeno, C 1 -C 4 alkyl, or any other groups defined herein, and R 2 represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoro Methyl, C 1 -C 3 alkyl, C 1 -C 3 alkoxy, C 1 -C 3 alkylsulfanyl, —NR 3 R 4 where R 3 and R 4 may be the same or different and each is hydrogen or C 1 -C 3 alkyl], or R 5 X 1 -wherein R 5 and X 1 are as described above. |
| priorityDate | 2000-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 479.