| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cbffa3b81b3b862dc7220b5648f5f745 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-22056
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-57 |
| filingDate |
2001-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea9896816d4508147a1603148cdecdb7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_977feb26e5df0c1de9bea46bea74091d |
| publicationDate |
2003-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20030024290-A |
| titleOfInvention |
Inhibition of apoptosis by the expression of antisense RNA of caspase-3 |
| abstract |
The present invention relates to an antisense nucleotide to caspase-3, an expression vector thereof, and a method of inhibiting apoptosis of recombinant CHO (chinese hamster ovary) cells using the same. An antisense nucleotide consisting of the nucleotide sequence of SEQ ID NO: 3 that inhibits the expression of caspase-3, an expression vector comprising the antisense nucleotide and expressing the antisense RNA for caspase-3 and the expression vector are introduced into recombinant cells A method of inhibiting recombinant cell proliferation by inhibiting the expression of caspase-3 by expressing antisense RNA against caspase-3. According to the present invention, by effectively inhibiting the activity of caspase-3 involved in cell death, cell death can be prevented, and by preventing cell death, the quality of the protein produced by the cell can be improved. It has an effect. |
| priorityDate |
2001-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |