| abstract |
The present invention provides a compound of formula (I) in the manufacture of a medicament for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, viral diseases and inflammatory disorders, as well as It relates to the use of pharmaceutically acceptable salts, hydroxides or solvent compounds thereof.n n n Formula In n n n n n n n Where T isn n n I) thienyl optionally substituted with halogen; orn n n II) phenyl optionally substituted with halogen and / or C 1-6 -alkyl;n n n E is a bond, -CH 2- , CO-;n n n L is a bond, -CH 2- , -CHR 4 -or -NR 3- ;n n n R 3 is H, C 1-6 -alkyl, C 1-6 -acyl or —COR 4 ;n n n R 4 is morpholino or C 1-6 -amido;n n n R 6 and R 7 are independently hydrogen or C 1-6 -alkyl; Andn n n R 8 and R 9 are independently hydrogen or C 1-6 -alkyl.n n n Formula I |