| abstract |
The present invention provides the use of a compound of formula (I) or a salt, ester or amide thereof in the manufacture of a medicament for use in the inhibition of Aurora 2 kinase:n n n n Formula In n n n n n n n n Wheren n n X is O, S, S (O), S (O) 2 or NR 6 , wherein R 6 is hydrogen or C 1-6 alkyl;n n n R 5 is an optionally substituted 5 membered heteroaromatic ring;n n n R 1 , R 2 , R 3 , R 4 are independently selected from a variety of specific moieties.n n n Certain compounds are novel and they are described herein with the pharmaceutical compositions containing them and are claimed as patent rights. |