abstract |
The present invention relates to a recombinant plasmid pGHOPG (KCTC 1019BP) that produces human osteoprotegerin (hOPG), and more specifically, to promoter and human growth of a 5.5 kb beta-casein gene derived from black goat. Novel plasmid pGHOPG (KCTC 1019BP) containing exons 1, 2, intron 1 and transcription terminators of hormone genes, and human OPG cDNA and transformed mammals using them to produce tissue-specific biological activity only in the mammary gland It relates to a method for stably producing milk containing hOPG. |