| abstract |
The present invention provides substituted thieno [2,3-b] pyrrolidin-5-ones of formula (I). The compounds are useful as inhibitors of cell production of tumor necrosis factor (TNF-α) and as antiproliferative agents and therefore useful for the treatment of neurodegenerative diseases, cardiovascular diseases, cancers or inflammatory diseases.n n n Formula In n n n n n n n Wherein R 1 , R 2 and R 3 have the values given in the specification. |