| abstract |
The present invention provides compounds that inhibit both an effective amount of acyl-coenzyme A: cholesteryl acyltransferase (ACAT) and acyl-coenzyme A: fatty alcohol acyltransferase (AFAT) in patients in need of treatment ([(2 Sebum production, comprising administering 4,6-triisopropyl-phenyl) -acetyl] -sulfamic acid 2,6-diisopropyl-phenyl ester or a pharmaceutically acceptable salt or solvent mixture thereof) To inhibit and treat sebaceous gland disorders. The methods of the present invention are effective in treating sebaceous gland disorders including oily skin, acne, seborrhea, perioral dermatitis, red nose and corticosteroid-induced acne damage, which are caused by or worsen the sebum overproduction. |