http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20030009903-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4a7711656877c108fcffc1b2b52cfc4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-061 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 |
| filingDate | 2001-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4b346cfb12cb8e244d5a29ee437f539 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7702a1c9da95a13117706a4a51643c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b02861f873e8d6e0dbe1615be7bea7bf |
| publicationDate | 2003-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20030009903-A |
| titleOfInvention | A preparation method of p-Nitrophenylsulfonylethoxycarbonyl protected PNA monomer as the amino protected group of 2-aminoethylglycine backbone |
| abstract | The present invention relates to a method for preparing a peptide nucleic acid monomer (Peptide Nucleic Acid; hereinafter referred to as 'PNA') in which the primary amino group of the main chain 2-aminoethylglycine is protected with p-nitrophenylsulfonylethoxycarbonyl group. Preferably 2-aminoethylglycine and p-nitrophenylthioethoxycarbonyl group protected by p-nitrophenylthioethoxycarbonyl group prepared by protecting the primary amino group in the backbone of the backbone 2-aminoethylglycine group P-nitrophenylthioethoxycarbonyl group / 4 by reacting a nucleobase group protected by a 4-methoxyphenyldiphenylmethyl group prepared by protecting a primary amino group of a cleobase group with a 4-methoxyphenyldiphenylmethyl group After preparing a PNA monomer protected with -methoxyphenyldiphenylmethyl group, the p-nitrophenylthioethoxycarbonyl group was finally p-nitrophenylsulfonylethoxycar by oxidation reaction. P-nitrophenyl, which is a base-sensitive main chain protecting group in the preparation of a conventional PNA monomer, by preparing a PNA monomer protected by p-nitrophenylsulfonylethoxycarbonyl group / 4-methoxyphenyldiphenylmethyl group by conversion to a carbonyl group Solving the problem that the sulfonylethoxycarbonyl group is partially removed from the hydrolysis reaction to reintroduce the protecting group reagent, it is economical, it is easy to introduce the PNA monomer protecting group, and the PNA monomer can be prepared in high yield. The present invention relates to a process for preparing PNA monomers which facilitates the preparation of PNA oligomers useful for diagnostic probes by effectively deprotecting the protecting groups of the PNA monomers under mild conditions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20030042180-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100464261-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100464264-B1 |
| priorityDate | 2001-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.