| abstract |
The present invention relates to compositions and methods for controlled release of one or a plurality of proteins or peptides. The composition consists of a biocompatible polymer matrix, proteins and / or peptides, insoluble particles. The protein is anchored to insoluble biocompatible particles by absorption or other mechanism, where the protein-particle combination is dispersed within the polymer matrix. The fixation of proteins in the particles serves to regulate the release of proteins or peptides from various drug forms, including long-acting dosage systems. |