http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20030008948-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_143ac4fbe1e063c6a828a96cfffc34d5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 |
| filingDate | 2001-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_870d43eb70e72876ad93f5e29e716c69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1495f12eb6d45511d09b3e019933e07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e859668807c699a12ad8721bd1d1482 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1767ffa698140387e386d643b11f5c10 |
| publicationDate | 2003-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20030008948-A |
| titleOfInvention | Process for the preparation of ondansetron and pharmaceutically acceptable salts thereof |
| abstract | The present invention provides 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl) methyl] -4H-carbazole represented by the following formula (1): A method for preparing -4-one (ondansetron) and pharmaceutically acceptable salts thereof, wherein the 1-substituted methyl-2-methylimidazole derivative of formula (2) and 1, 2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one is reacted in the presence of a Lewis acid catalyst in a suitable solvent to synthesize a target compound in a simple, economical and high purity. It is about.n n n n n n n n n n n n n n n n n n Wherein R 1 is R 2 R 3 N-, 1-morpholinyl, or halogen, and R 2 and R 3 are each C 1 -C 5 lower alkyl, benzyl, alkoxy, or the like, or R 2 and R 3 together represents a cyclic alkyl C 1 -C 5. |
| priorityDate | 2001-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 106.