| abstract |
The present invention relates to a composition for the protection, growth promotion and regeneration of nerve cells containing berberine, derivatives thereof and pharmaceutically acceptable salts thereof. The composition of the present invention is apoptosis defense effect in neural stem cells, apoptosis defense effect in differentiated neuronal cell line, neuronal differentiation inducing effect, regeneration effect of neurites, central nerve regeneration effect, peripheral nerve regeneration effect, neuromuscular junction The effect of remodeling, neurodegenerative protection and regeneration of dementia and cerebral ischemia was excellent.n n n Therefore, the present invention can be very useful as an agent for preventing and treating various kinds of degenerative neurological diseases, ischemic neurological diseases or neuroinjury diseases and for improving learning ability. |