http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20030005205-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2001-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20030005205-A |
| titleOfInvention | Processes for the production of thienopyrimidine derivatives |
| abstract | The present invention provides methods for the industrial large-scale preparation of intermediates for the preparation of thienopyrimidine derivatives exhibiting GnRH antagonism. Specifically, as a method for preparing a compound of formula (III) or a salt thereof:n n n [Formula III]n n n n n n n n (Wherein R 1 is hydrogen, nitro, halogeno, phthalimido, mono- or di- (alkylcarbonyl) amino, or alkoxy; R 2 is alkyl or aryl),n n n The compound of formula (I) or a salt thereof is converted to the corresponding acid halide, the acid halide is reacted with malonic ester and magnesium alkoxide, the product obtained is treated with an acid and the resulting product is first-class Provided is a method comprising reacting with sulfur and a compound of formula: NCCH 2 COOR 2 or a salt thereof in the presence of an amine:n n n [Formula I]n n n n n n n n The method makes it possible to produce thienopyrimidine derivatives exhibiting GnRH antagonism on a large scale with high efficiency and high yield on an industrial scale by simple means. |
| priorityDate | 2000-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 167.