| abstract |
Excellent β cyclase inhibitors are provided comprising a compound of Formula I or salts thereof:n n n [Formula I]n n n n n n n n Wherein Ar is an aromatic group; X is -O-, -S-, -CO-, -SO-, -SO 2- , -NR 8- , -CONR 8- , -SO 2 NR 8- , And a divalent group selected from -COO-, wherein R 8 is hydrogen, etc., a divalent C 1-6 aliphatic hydrocarbon group which may include one or two of said divalent groups, or a free valency; A divalent group selected from -O-, -S-, -CO-, -SO-, -SO 2- , -NR 8- , -CONR 8- , -SO 2 NR 8- , and -COO-, or A divalent C 1-6 aliphatic hydrocarbon group which may contain one or two of said divalent groups; R 1 and R 2 are each hydrogen, a hydrocarbon group, etc .; A is a ring which may be further substituted). |