| abstract |
In host animals, methods and pharmaceutical compositions are provided for enhancing endogenous immune response-mediated clearance of this pathogenic cell population as pathogenic cells that preferentially express, uniquely express or overexpress binding sites for specific ligands. . The present invention includes administering a ligand conjugated to an immunogen to a host animal containing a pathogenic cell population. Existing antibodies that act against the immunogen or antibodies administered to a host animal to achieve passive immunity bind to the ligand-immunogen conjugate, resulting in the removal of pathogenic cells by the host's immune response. At least one additional treatment selected from the group consisting of apoptosis agents, tumor penetration enhancers, chemotherapeutic agents, antimicrobials, cytotoxic immune cells, and compounds capable of stimulating endogenous immune responses and not binding to ligand-immunogen conjugates Administer the factor. |