http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20020081479-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-502 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 |
| filingDate | 2001-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20020081479-A |
| titleOfInvention | 4-Oxo-1,4-Dihydro-3-Cinnolinecarboxamides As Antiviral Agents |
| abstract | A compound of formula I or a pharmaceutically acceptable salt thereofn n n <Formula I>n n n n n n n n Wheren n n A is (a) Cl, (b) Br, (c) CN, (d) NO 2 or (e) F,n n n R 1 is (a) R 5 or (b) SO 2 R 9 ,n n n R 2 , R 3 and R 4 may be the same or different and include (a) H, (b) halo, (c) aryl, (d) S (0) m R 6 , (e) (C═O) R 6 , (f) (C = O) OR 9 , (g) cyano, (h) het bonded via a carbon atom, (i) OR 10 , (j) Ohet, (k) NR 7 R 8 , ( l) SR 10 , (m) Shet, (n) NHCOR 12 , (o) NHSO 2 R 12 , (p) may be partially unsaturated, R 11 , OR 13 , SR 10 , SR 13 , NR 7 R 8 , halo, (C = O) C 1-7 alkyl, or SO m R 9 group, or C 1-7 alkyl which may be optionally substituted by one or more substituents (q) R 3 together with R 2 or R 4 oR Forms carbocyclic or het, which may be optionally substituted by C 1-7 alkyl or NR 7 R 8 , which may be optionally substituted by 14 , andn n n R 5 is (a) (CH 2 CH 2 O) i R 10 , (b) OC 2-4 alkyl, which may be partially unsaturated and further substituted by het, OR 10 or NR 7 R 8 , C 1-7 alkyl optionally substituted with one or more substituents selected from the group consisting of NR 7 R 8 , R 11 and SO m R 9 or (c) partially unsaturated, R 11 , NR 7 R 8 or SO and m R 9, optionally by C 1-7 alkyl which may be substituted, R 11, NR 7 R 8 and SO m R 9 a by one or more substituents selected from the group consisting of optionally substituted C 3-8 cycloalkyl,n n n R 6 is (a) C 1-7 alkyl, (b) NR 7 R 8 , (c) aryl or (d) het bonded via a carbon atom,n n n R 7 and R 8 may independently be (a) H, (b) aryl, (c) partially unsaturated, and aryl, NR 10 R 10 , R 11 , SO m R 9 , CONR 10 R 10 and halo a C 1-7 optionally substituted by one or more substituents selected from the group consisting of alkyl, (d) can be partially unsaturated, R 11, NR 7 R 8, or SO m R 9, optionally substituted by C 1-7 alkyl Or C 3-8 cycloalkyl optionally substituted by one or more substituents selected from the group consisting of R 11 , NR 7 R 8 and SO m R 9 , or (e) R 7 and R 8 combine with nitrogen to form a het and,n n n R 9 may be (a) aryl, (b) het, (c) C 3-8 cycloalkyl, (d) methyl or (e) partially unsaturated, NR 10 R 10 , R 11 , SH, CONR 10 C 2-7 alkyl optionally substituted by one or more substituents selected from the group consisting of R 10 and halo,n n n R 10 is C 2-7 alkyl optionally substituted by (a) H, (b) methyl or (c) OH,n n n R 11 may be (a) OR 10 , (b) Ohet, (c) Oaryl, (d) CO 2 R 10 , (e) het, (f) aryl, (g) CN or (h) partially unsaturated number and, R 11, NR 7 R 8, or SO m R 9, optionally substituted by a C 1-7 alkyl, R 11, NR 7 R 8 and SO m R 9, optionally substituted by one or more substituents selected from the group consisting of C 3-8 cycloalkyl, which may ben n n R 12 is C 2 optionally substituted by (a) H, (b) het, (c) aryl, (d) C 3-8 cycloalkyl, (e) methyl or (f) NR 7 R 8 or R 11 -7 alkyl,n n n R 13 is (a) (P = O) (OR 14 ) 2 , (b) CO (CH 2 ) n CON (CH 3 )-(CH 2 ) n SO 3 - M + , (c) amino acid, (d ) C (= 0) aryl, (e) NR 7 R 8 , aryl, het, C0 2 H or C (= 0) C 1-7 alkyl optionally substituted by O (CH 2 ) n CO 2 R 14 ,n n n R 14 is (a) H or (b) C 1-7 alkyl,n n n Each i is independently 2, 3 or 4,n n n Each n is independently 1, 2, 3, 4 or 5,n n n Each m is independently 0, 1 or 2,n n n M is sodium, potassium or lithium,n n n Aryl is a phenyl radical or an ortho-fused bicyclic carbocyclic radical wherein at least one ring is aromatic,n n n Wherein any aryl is C 1-6 alkyl, halo, OH, cyano, CO 2 R which may be further substituted by 1 to 3 SR 14 , NR 14 R 14 , OR 14 or CO 2 R 14 Optionally substituted with one or more substituents selected from the group consisting of 14 , CF 3 and C 1-6 alkoxy,n n n het is a 4, 5, 6 or 7-membered saturated or unsaturated heterocyclic ring having 1, 2 or 3 heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen, which is a benzene ring or any bicyclic heterocycle Optionally fused with groups,n n n Wherein any het is C 1-6 alkyl, halo, OH, cyano, phenyl, CO which may be further substituted by 1 to 3 SR 14 , NR 14 R 14 , OR 14 or CO 2 R 14 2 R 14 , CF 3 , C 1-6 is optionally substituted with one or more substituents selected from the group consisting of alkoxy, oxo and oxime. The compound is particularly effective for the treatment or prevention of herpes virus. |
| priorityDate | 2000-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 345.