| abstract |
The present invention provides pyrimidine derivatives of formula (I), or a pharmaceutically acceptable salt or in vivo hydrolyzable ester thereof:n n n n n n n n In the above formula,n n n Q 1 and Q 2 are independently selected from optionally substituted aryl or carbon linked heteroaryl as defined herein; One of Q 1 and Q 2 or both Q 1 and Q 2 are substituted on the ring carbon by a substituent of one of the formulas (Ia) or (Ia ′) below;n n n n n n n n n Wheren n n Y, Z, n, m, Q 3 , G, R 1 are as defined herein.n n n The present invention also provides a method for preparing the derivative, a pharmaceutical composition containing the derivative, and the use of the derivative as a cyclin dependent serine / threonine kinase (CDK) and focal adhesion kinase (FAK) inhibitor. |