| abstract |
The present invention relates to a percutaneous contraceptive delivery system (TCDS) for controlling pregnancy rate in women, comprising a contiguous layer of a solid absorbent adhesive polymer matrix in which the lowest effective daily dose of estrogen and progestin is dispersed and released for percutaneous absorption. will be. Presently preferred is to use ethynyl estradiol, a synthetic estrogen, and levonorgestrel, a synthetic progestin. Together with these two steroidal contraceptives, a combination of several chemical skin penetration enhancers, including capric acid, in specific weight ratios ranging from 2.0: 1: 1: 0.8 to 6; 1: 1: 0.8, are uniformly dispersed in the adhesive polymer matrix. do. The present invention also provides a method of controlling pregnancy rate using a transdermal contraceptive delivery system. |