| abstract |
Compounds of Formula I and salts thereof:n n n n n n n n Wherein R 1 is a hydrogen atom, a substitutable hydrocarbon group, a substitutable non-aromatic hydrocarbon group, and R 2 is a substitutable hydrocarbon group, a substitutable non-aromatic hydrocarbon group, or R 1 and R 2 is a group can create a heterocyclic which may be substituted are combined with one another, and A; A is N or N + -R 5 and Y - (R 5 is a hydrocarbon group; Y - is an anion pair), and; R 3 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R 4 is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, An alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted; E is a divalent aliphatic hydrocarbon group which may be substituted with a group (s) other than an oxo group; G 1 is a bond, CO Or SO 2 G 2 is CO, SO 2 , NHCO, CONH or OCO; J Is a methine or nitrogen atom; each Q and R is a divalent C 1-3 aliphatic hydrocarbon which may be bonded or substituted; provided that J is methine when G 2 is OCO, the other is one of Q and R Is not a bond, and when G 1 is a bond, each of Q and R is not substituted with oxo group (s)) has a strong CCR5 antagonism, preventing or preventing various HIV infectious diseases (eg, AIDS) in humans. It can be advantageously used for treatment. |