| abstract |
The present invention relates to oxadiazole derivatives represented by formula (I) and to nontoxic salts thereof:n n n n Formula In n n n n n n n n Wherein R is hydrogen, alkyl, CycA, or the like; AA 1 is a single bond, an amino acid residue, or the like; AA 2 is a single bond, an amino acid residue, or the like; R 7 , R 8 are hydrogen, alkyl and the like; R 9 is hydrogen, alkyl; R 10 is hydrogen, alkyl or the like.n n n Compounds of formula (I) have cysteine protease inhibitory activity, inflammatory diseases, diseases caused by apoptosis, diseases caused by abnormal immune responses, autoimmune diseases, diseases caused by degradation of biological proteins, shock, circulatory disorders, blood coagulation systems Useful as a prophylactic and / or therapeutic agent for abnormalities, malignancies, acquired immunodeficiency syndrome (AIDS) and AIDS-related diseases (ARC), parasitic diseases, neurodegenerative diseases, lung disorders, bone absorptive diseases, anti-endocrine diseases, etc. Do. |