| abstract |
Compounds represented by the formula (I) have an elastase inhibitory action and are caused by disorders of elastin degradation by elastase, degradation of collagen fibers and / or abnormal proteoglycan degradation such as emphysema, chronic arthritis rheumatoid, atherosclerosis It is useful for the treatment and / or prevention of adult respiratory distress (ARDS), myocardial infarction, ulcerative colitis, periodontal disease and the like.n n n Formula In n n n n n n n In the above formula, all symbols are as defined in the detailed description of the invention. |