http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20020045445-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_20d47b2efadbe3e13dc49c01d30f108a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 2000-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4d3b99ff603db3bf922066fe41154fb |
| publicationDate | 2002-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20020045445-A |
| titleOfInvention | Screening methods for the detection of multidrug resistance protein inhibitors and reactive oxygen species-producing cytotoxic substances using the doxorubicin-resistant acute myelocytic leukemia subline AML-2/DX100 |
| abstract | In the present invention, resistant cells (AML-2 / DX100) prepared by treating doxorubicin, an anticancer antibiotic, are overexpressed in multidrug resistance-associated protein (MRP) in acute myeloid leukemia cell line. It is intended to be used to screen inhibitors (FIG. 1). In addition, AML-2 / DX100 was found to be more susceptible to cytotoxic substances such as paraquat, a superoxide-producing species, hydrogen peroxide (H2O2), and t-butyl hydroperoxide. 2). The inventors of AML-2 / DX100 as a protective mechanism against reactive oxygen species (superoxide, hydrogen peroxide, radical hydroxide), superoxide dismutases, glutathione s-transferase, catalase, glutathione reductase, glutathione peroxidase, glucose-6-phosphate dehydrogenase ), The non-enzymatic system (metallothionein (BCL-2)) and all other defense mechanisms were not different from the wild type (WT), but only catalase (catalase) was reduced to only one third (Fig. 1). Therefore, the present inventors also intend to use the cells to screen for cytotoxic substances that produce reactive oxygen species. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100678146-B1 |
| priorityDate | 2000-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 210.