http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20020040657-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 |
| filingDate | 2000-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20020040657-A |
| titleOfInvention | Process for preparing MKC-442 |
| abstract | A process for preparing 6-benzyl-1- (ethoxymethyl) -5-isopropyluracil, also known as MKC-442, is disclosed. This method comprises ethyl-2-isopropyl-3, including from zinc and benzyl cyanide and ethyl-2-bromo-3,3-dimethyl-propiotate activated in the Reformatsky reaction using any known method. Methods for synthesizing isopropyl β-ketoesters, such as -oxo-4-phenyl-butyrate. The ethyl-2-isopropyl-3-oxo-4-phenyl-butyrate is then condensed to thiourea in one of two ways. First, ethyl-2-isopropyl-3-oxo-4-phenyl-butyrate is condensed to thiourea in a two-base system in the presence of a solvent. The second method of condensing ethyl-2-isopropyl-3-oxo-4-phenyl-butyrate with thiourea is carried out in the presence of potassium-t-butoxide to form benzyl isopropyl thiourea, which is step (B) Desulfurization at MKC-442 is prepared by alkoxyalkylation of the benzyl isopropyl uracil produced from either method. |
| priorityDate | 1999-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 139.