abstract |
The present invention is a sodium / proton exchange (NHE) inhibitor of the formula: EMI2.1 < tb > < tb > Heterocyclic, < / RTI >n n n n n n n n (A formula, n is 1 to 5, X is N or CR 5, and (where R 5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl), Z is a heteroaryl group, Wherein R 1 , R 2 , R 3 and R 4 are as defined herein, wherein X is N and R 1 is preferably aryl or heteroaryl,n n n In addition, the present invention provides a method for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis and arrhythmia using the above heterocyclic derivatives. |