| abstract |
Use of a compound of formula (I), or a salt, ester, amide or prodrug thereof, in the manufacture of a medicament for the inhibition of aurora 2 kinase:n n n (I)n n n n n n n n Wherein X is O, S, S (O) or S (O) 2 or NH or NR 12 wherein R 12 is hydrogen or C 1-6 alkyl;n n n R 5 is NHC (O) OR 9, NHC (O) R 9, NHS (O) 2 R 9, C (O) R 9, C (O) OR 9, S (O) R 9, S (O) oR 9, S (O) 2 oR 9, C (O) NR 10 R 11, S (O) NR 10 R 11, S (O) ONR 10 R 11 ( wherein, R 9, R 10 or R 11 are different Lt; / RTI > are selected from the group consisting ofn n n R < 6 > is hydrogen, optionally substituted hydrocarbyl or optionally substituted heterocyclyl;n n n R 7 and R 8 are various specific organic groups;n n n R 1, R 2, R 3 , R 4 is a halogeno, cyano, nitro, C 1-3 alkyl sulfanyl, -N (OH) R 13 - ( wherein, R 13 is hydrogen or C 1-3 alkyl Or R 15 X 1 - wherein X 1 is a direct bond, -O-, -CH 2 -, -OCO-, carbonyl, -S-, -SO 2 -, -NR 16 CO-, -CONR 16 -, -SO 2 NR 16 - , -NR 17 SO 2 - or -NR 18 - (wherein, R 16, R 17 and R 18 are each independently hydrogen, C 1-3 alkyl or C 1-3 alkoxy C And R < 15 > is hydrogen, optionally substituted hydrocarbyl, optionally substituted heterocyclyl or optionally substituted alkoxy. |