| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fa4c37b4aacb317ee027a1a729de4ff |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 |
| filingDate |
2000-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e64eb9aae5a9c9c7628c7589942496a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a61b39553748b78244ce6d6e7a787d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3358261f11b066106634f8bb3118149 |
| publicationDate |
2002-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20020032079-A |
| titleOfInvention |
Composition for transdermal delivery of methotrexate |
| abstract |
The present invention relates to a composition for transdermal administration containing methotrexate as an active ingredient. More specifically, the present invention relates to methotrexate, which exhibits pharmacological activity in the treatment of rheumatoid arthritis, as an active ingredient. By using a polyhydric alcohol having a solubility of 20 mg / g or more as a solvent, a sufficient amount of the drug is used in the transdermal composition, and fatty acids or fatty alcohols are included as skin permeation accelerators, thereby significantly improving the skin permeability of the drug. It relates to a composition for transdermal administration that can be usefully used for the treatment of rheumatoid arthritis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20180124412-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018208125-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100897915-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11253604-B2 |
| priorityDate |
2000-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |