| abstract |
The present invention relates to (R) -1- (3,5-bis (tri) by asymmetric mobile hydrogenation of 3,5-bis (trifluoromethyl) acetophenone using a rhodium catalyst or ruthenium catalyst and a ligand in the presence of an alcohol. Fluoromethyl) -phenyl) ethanol. In addition, the present invention is not only a specific complex of (S, R) -1-amino-2-hydroxyindane with rhodium and ruthenium, but also (R) -1- (3,5-bis (trifluoromethyl)- Phenyl) ethanol and 1,4-diazabicyclo [2.2.2] octane complex and (R) -1- (3,5-bis (trifluoromethyl) -phenyl) ethanol and 1,4-diazabi A method for purifying (R) -1- (3,5-bis (trifluoromethyl) -phenyl) ethanol using a 2: 1 complex with cyclo [2.2.2] octane. |