| abstract |
A molecule comprising an aminooxy group is provided, wherein the aminooxy group provides a binding site for the covalent attachment of another molecule. In one embodiment, there is provided a polyoxyethylene molecule comprising an aminooxy group that can be conjugated to a variety of biologically active molecules comprising a poly (amino acid). In other embodiments, aminooxy groups can be used to form covalent bonds with biological molecules such as poly (amino acids). The aminooxy group reacts with a modified poly (amino acid) containing a carbonyl group such as a glyoxyl group to form a conjugate of a valency platform comprising an amino group through an oxime bond. The valency platform molecules comprising aminooxy groups are advantageously reactive in conjugate formation and can also be used to form compositions having very low polydispersity. |