| abstract |
[Formula 1]n n n n n n n n Wherein R 1 and R 2 each independently represent a hydrogen atom or a lower alkyl group, R 3 represents a hydrogen atom, a halogen atom, a lower alkyl group, -OSO 2 NR 1 R 2 , a lower alkanoylamino group, a nitro group or a cyano group Represents A, a substituted or unsubstituted phenyl group, a group of the formula -X-NR 4 R 5 )n n n Phenylsulfate derivatives or salts thereof have excellent steroid sulfatase inhibitory effects, and diseases involving steroids such as estrogen, such as breast cancer, uterine carcinoma, endometrial hyperplasia, infertility, endometriosis, uterine adenomyosis, magnetism It is useful for the prevention or treatment of immune diseases, dementia or Alzheimer's disease. |