| abstract |
The present invention relates to 3-hydroxy-6-amino-chromen-4-one derivatives of the general formula (1) useful as inhibitors of cyclin dependent kinase (CDK), to pharmaceutically acceptable salts, hydrates, solvates and isomers thereof will be. The present invention also provides a method for preparing a compound of formula 1 and a disease related to cell proliferation such as cancer, inflammation, vascular stenosis and angiogenesis, comprising the compound of formula 1 as an active ingredient together with a pharmaceutically acceptable carrier. To inhibitors and therapeutic agents.n n n [Formula 1]n n n n n n n n In the above formula,n n n R 1 and R 2 are each hydrogen, alkyl, hydroxy alkyl, cycloalkyl, acetyl, benzyl, phenyl, or piperidinyl groups,n n n X represents hydrogen or halogen. |