| abstract |
The present invention relates to a process for preparing epirubicin and its pharmaceutically acceptable salts, the method comprising first protecting a 3'-amino group of a sugar moiety with doxorubicin as a starting material, alkyl ketalizing an aglycon moiety, and Introducing an activator at the 4'-position of the moiety, inverting and removing the activator at the 4'-position of the sugar part, hydroxylating the 4'-position of the inverted sugar moiety, a ketal derivative of aglycone It consists of the step of obtaining the epirubicin by the hydroxide, according to the production method of the present invention can be produced in high yield, high purity of the epirubicin represented by the formula (1). |