| abstract |
The present invention discloses MC-4 and / or MC-3 receptor ligands having a structure according to formula (I):n n n [Formula I]n n n n n n n n Wherein B, X, Z, D, G, R, R 1 , R 1 ′ , R 11 , m, n, p, and q are as described in the specification). The compounds are useful for the treatment of diseases mediated by MC-4 and / or MC-3 receptors. As such, the present invention relates to methods of treating weight disorders such as obesity, loss of appetite, and cachexia. The invention also relates to CNS dysfunction, behavioral disorders, memory-related disorders, cardiovascular function, inflammation, sepsis, septic shock, cardiac shock, hypo humoral shock, sexual dysfunction, impotence, muscle atrophy, nerve growth and recovery and Related diseases, and treatments related to intrauterine fetal growth. Also disclosed are pharmaceutical compositions containing a compound of formula (I). |