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classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06
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classificationIPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
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filingDate 2000-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99f872572947880bce28e266427ea7a3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f33b01c29309699ef86aa2af9272f24
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publicationDate 2002-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20020004971-A
titleOfInvention Substituted proline derivatives and medicinal compositions containing the same
abstract Formula (1)n n n n n n n n (Wherein R 1 is a structural formula (2)n n n n n n n n And the like, where A isn n n n n n n n ego,n n n R 2 represents a hydrogen atom or lower alkyl,n n n R 3 represents lower alkyl, aryl or lower alkoxy which may be substituted;n n n R 4 represents a hydrogen atom, optionally substituted lower alkyl, lower alkylcarbonyl, lower alkylsulfonyl or lower alkoxycarbonyl,n n n R 0 represents a hydrogen atom or lower alkyl,n n n B represents CH 3 or S,n n n n represents an integer of 1 to 3.) The proline derivatives or stereoisomers thereof or their pharmaceutically acceptable salts exhibit excellent antithrombin activity and are useful as medicines for antithrombotic agents and the like. It is possible to have fewer side effects.
priorityDate 1999-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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