| abstract |
The present invention relates to glycoprotein VI (GPVI), its isolation, purification and methods of preparing recombinants. In particular, the present invention relates to the use in the treatment of pathological events and disorders that are directly or indirectly correlated with blood coagulation disorders such as thrombosis and cardiovascular disease of GPVI, preferably recombinant GPVI. Extracellular recombinant proteins can also be used to establish screening assays to find potential inhibitors of membrane-bound GPVI to inhibit the binding of platelets and collagen. Changes in GPVI can be used to monitor exposure to thrombosis and cardiovascular disease and platelet aging. |