| abstract |
The present invention relates to the use of certain low affinity NMDA antagonists as antidepressants. Preferred are the compounds of formula (I) and their pharmaceutically acceptable salts.n n n <Formula I>n n n n n n n n In the formula,n n n R 1 is pyridyl, phenyl or 4-fluorophenyl;n n n R 2 is phenyl or 4-fluorophenyl;n n n R 3 is hydrogen, C 1-6 alkyl or methoxycarbonyl;n n n R 4 is hydrogen or methyl;n n n R 5 is hydrogen or COCH 2 NH 2 . |