| abstract |
The present invention relates to a method for increasing the number of white blood cells (WBC) in an animal subject using the compound of formula (I). These compounds are effective amounts of a compound of formula (I) or a pharmaceutically acceptable salt thereof to increase the WBC of a subject.n n n Formula 1n n n Z-linkage-Z 'n n n In the above formula (1)n n n Z is a cyclic polyamine containing 9 to 32 rings (3 to 8 of which are nitrogen atoms separated from each other by two or more carbon atoms), wherein the heterocycle optionally contains additional heteroatoms in addition to nitrogen And / or may be fused to an additional ring system,n n n Z 'can take the form as defined above for Z, or can be a radical of formula (2)n n n A "bond" may represent a bond or an alkylene (1-6C), or may contain an oxygen atom contained in the aryl, fused aryl, or alkylene chain, or may contain a keto group, a nitrogen atom or a sulfur atom.n n n (2)n n n -N (R) - (CR < 2 > ) n -Xn n n In the above formula (2)n n n R is each independently H or a straight chain, branched or cyclic alkyl (1-6C)n n n n is 1 or 2,n n n X is an aromatic ring containing a heteroaromatic ring or mercaptan. |