| abstract |
The present invention relates to novel penicylamine or S-nitrosothiol derivatives of glutathione corresponding to the general formula (I)n n n n n n n n Wherein A and B are phenyl groups or A and B together form a 6-membered ring -CH 2 -Q-CH 2 -radical wherein Q represents an oxygen atom, a sulfur atom or an NR 3 group, wherein R 3 is hydrogen or a C 1 -C 4 alkyl group; R 1 is an acyl radical, which may be a radical of glutamic acid bound via a C 1 -C 5 aliphatic acyl group or a carboxyl group that is not an amino acid; R 2 is a hydroxyl group or glycine radical bonded via a peptide bond; Provided that when R 1 is an aliphatic acyl radical, R 2 is a hydroxyl group and when R 1 is a radical of glutamic acid, R 2 is a glycine radical. The compounds exhibit vasodilatory and platelet aggregation inhibitory effects and are useful for the treatment of circulatory dysfunction, especially cardiovascular dysfunction. |