| abstract |
The present invention relates to a poly (ADP-ribose) polymerase inhibitor containing the 2H-phthalazin-1-one derivative represented by the formula (I) and a salt thereof as an active ingredient, wherein the symbols in the formulas are as described in the specification. will be.n n n Compounds of formula (I) inhibit poly (ADP-ribose) polymerase and are used in various ischemic diseases (brain, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebral sclerosis, arthritis, etc.), It is useful as a prophylactic and / or therapeutic agent for neurodegenerative diseases (conjugated ectopic disorders, Alzheimer's disease, muscular dystrophy, etc.), diabetes mellitus, shock, head trauma, kidney failure, hyperalgesia, etc. It is also useful as a sensitizer for therapy.n n n Formula I |