| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G02C7-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-282
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 |
| filingDate |
2000-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b945a46ee78e22c7d1b65b5bf8a63f62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d937e1c67e331c7ac6e20cad567a48c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_945376b40f6296281895f3245f692f08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f105caf55299d4ddf71ae8e69e2dca4d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d4576ba884d491c3316a84f167e5588
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fff0203c87456640e1a9393755bba099
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7e9ae3b914812a700ef9003bd2d156e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb2a6043165eb176581e3e6b7bdc8e86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef2f5978a06b8e5e717a50f16e3c9001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d0f6ff10b6ea863a04cab233f8992b3 |
| publicationDate |
2001-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20010095468-A |
| titleOfInvention |
A process for the isolation of compound scopoletin useful as nitric oxide synthesis inhibitor |
| abstract |
FIELD OF THE INVENTION The present invention relates to a method for separating scopoletin compounds used as inhibitors of nitric oxide synthesis from plants of Artemisia annua and other families, wherein aqueous powders of acetonitrile solvents in dry water from various plant parts in a ratio of 1: 5. Extracting for 6 to 8 hours; Concentrating the extracted solvent under vacuum to 30% of the original extract; Distributing the concentrated extract with a halogenated solvent to transfer the scopoletin to a nonpolar halogenated solvent; Drying the halogenated solvent with anhydrous sodium sulfate and evaporating the solvent; Crystallizing the residue in methanol and filtering the crystals; Concentration of the filtrate by chromatography on silica gel; Eluting scopoline in a chloroform methanol mixture and crystallizing the fraction containing scopoline to obtain a pure scopoline compound. |
| priorityDate |
2000-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |