abstract |
The present invention relates to novel angiogenesis inhibitory proteins associated with thrombospondine. More specifically, isolated nucleic acid molecules encoding human METH1 and METH2 are provided. Also provided are METH1 and METH2 polypeptides, as well as recombinant methods, vectors, and host cells for preparing the same. The present invention also provides a therapeutic method for treating a patient in need of an increased amount of METH1 or METH2 and a diagnostic method for measuring the prognosis of cancer. |