abstract |
The present invention relates to compositions and methods for the treatment of malignant diseases such as leukemia and cancer. The compositions of the present invention comprise one or more WT1 polynucleotides, WT1 polypeptides, antigen-presenting cells providing WT1 polypeptides, antibodies that specifically bind to WT1 polypeptides, or T cells that specifically react with WT1 polypeptides. Include. Such a composition can be used, for example, for the prevention and treatment of metastatic disease. |