| abstract |
Derivatives of aryl (or heteroaryl) azolylcarbinol (I) are useful in the treatment of diseases mediated by excessive substance P in mammals including humans, in particular anxiety, depression, schizophrenia, bipolar disorder, sexual dysfunction, drug addiction, Motor disorders, etc., wherein Ar is an optionally substituted phenyl or thienyl radical; R1 is a hydrogen atom, a cyclohexyl group, N- methyl-piperidyl group, a phenyl group, a vinyl group or a C 1 -C 4 alkyl group; R2 is a hydrogen atom, dialkylaminoalkyl, alkyl azaheterocycloalkyl, or azaheterocyclylalkyl; Het is optionally substituted with a heterocycle nitrogen pentagonal ring having one to three nitrogen atoms. |