| abstract |
The present invention relates to a novel use of histone H2A or H2B, and relates to a composition containing histone H2A, H2B or a fragment thereof as an active ingredient, which can alleviate all symptoms of progressive, inflammatory autoimmune arthritis. The pharmaceutical composition according to the present invention contains histone H2A, H2B, or a fragment thereof as an active ingredient, and if necessary, may contain a pharmacologically acceptable carrier, and effectively reduce arthritis incidence and arthritis index for rheumatoid arthritis. . |